Thermo Scientific - Microplate Reader Literature Library

Welcome to the microplate instrumentation Reading Room, where you can download technical notes, applications notes and research papers discussing investigations that were made possible by Thermo Scientific microplate readers.

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Multiskan FC

Technical Note

Determination of Clenbuterol from Bovine Urine Samples

Application Notes

An Easy Determination of the Antioxidant Power of Beverage Samples
An Easy Way to Perform Cytotoxicity Assays with Frozen Cells
High Sensitivity ELISA Assays for the Detection of Melamine Residuals in Milk
How to Perform a Qualitative/Quantitative ELISA Assay to Detect H. pylori
High-Throughput Enzyme Linked Immunosorbent Assay Performed by Molecule Immobilization on the Surface of Magnetic Particles
Kinetic Measurements of Antibiotic Susceptibility Studies with a Microplate Photometer
Performing a Qualitative HIV ELISA Assay
Rapid and Reproducible Protein Quantitation
Total Protein Quantification
Turbidometric Growth Curve Measurements and Liquid Evaporation Studies
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays

Multiskan Spectrum

Research Papers

A Universal Protein-Protein Interaction Motif in the Eubacterial DNA Replication and Repair Systems
Advanced Glycation End-Products and Advanced Oxidation Protein Products in Patients with Diabetes Mellitus

Varioskan Flash

Technical Note

Internal Calibration System of Thermo Scientific Varioskan Flash with Improved Sensitivity, Accuracy and Dynamic Range

Application Notes

Characterization of Emission Properties of Aequorin Mutants with Rapid, High Throughput Screening Assay
Comparison of Flash and Glow ATP Assays with Thermo Scientific Varioskan Flash Luminometry
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Quantitative Determination of Progesterone in Serum Samples
Kinetic Measurements of Antibiotic Susceptibility Studies with a Microplate Photometer

Research Papers

A Rapid Screening Method for Detecting Active Compounds against Erythromycin-Resistant Bacterial Strains of Finnish Origin
Assessing the Data Quality in Predictive Toxicology using a Panel of Cell Lines and Cytotoxicity Assays
Attenuated Cytotoxicity but Enhanced bfibril of a Mutant Amyloid b-Peptide with a Methionine to Cysteine Substitution
Caspase-Independent Cell Death by CD300LF (MAIR-V), an Inhibitory Immunoglobulin-Like Receptor on Myeloid Cells
Cellular Inhibition of Protein Tyrosine Phosphatase 1Bby Uncharged Thioxothiazolidinone Derivatives
Differential Modulation of Alzheimer's Disease Amyloid b-Peptide Accumulation by Diverse Classes of Metal Ligands
Effects of Toxic Cellular Stresses and Divalent Cations on the Human P2X7 Cell Death Receptor
Endostar Suppresses Invasion Through Downregulating the Expression of Matrix Metalloproteinase-2/9 in MDA-MB-435 Human Breast Cancer Cells
Evaluation of Natural Products in Apoptosis, Protein Kinase C Activation and Caco-2 Cell Permeability
Functional and Structural Characterization of a Prokaryotic Peptide Transporter with Features Similar to Mammalian PEPT1
Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells
One-pot Preparation of Coenzyme A Analogues via an Improved Chemo-Enzymatic Synthesis of Pre-CoA Thioester Synthons
PA3719-Mediated Regulation of the MexAB-OprM Efflux System of Pseudomonas Aeruginosa
Protein kinase signaling: Intracellular messengers as potential targets for intervention in renal disease
Tacrolimus-Induced Diabetes in Rats Courses with Suppressed Insulin Gene Expression in Pancreatic Islets
Tyrosinase and laccase as novel crosslinking tools for food biopolymers

Appliskan

Application Notes

Luminometric Sensitivity of the Thermo Scientific Appliskan Multimode Reader
TRF Performance of Thermo Scientific Appliskan with Europium Sensitivity Assay

Research Papers

Hypoglycemic Effect of Aspalathin, a Rooibos Tea Component from Aspalathus Linearis, in Type 2 diabetic Model db/db Mice
Lipoteichoic Acid Induces HO-1 Expression via the TLR2/MyD88/c-Src/NADPH Oxidase Pathway and Nrf2 in Human Tracheal Smooth Muscle Cells
Multiple Functions of Short Synthetic Enantiomeric Peptides Based on Beetle Defensins
Proteomic screening of variola virus reveals a unique NF-KB inhibitor that is highly conserved among pathogenic orthopoxviruses
Sensitive Aflatoxin B1 Determination Using a Magnetic Particles-Based Enzyme-Linked Immunosorbent Assay
Transduction Efficiency and Immune Response Associated With the Administration of AAV8 Vector Into Dog Skeletal Muscle

Fluoroskan Ascent FL

Application Notes

Studying the Affinity of Different Ligands to Estrogen Receptor-α

Research Papers

IsolationC characterization and Activity of Diapocynin, an Apocynin Metabolite
4-Aminopyridine Decreases Progesterone Production by Porcine Granulosa Cells
A Protocol for the Fluorometric Quantification of mGFP5-ER and sGFP(S65T) in Transgenic Plants
Arginine to Lysine 108 Substitution in Recombinant CYP1A2 Abolishes Methoxyresorufin Metabolism in Lymphoblastoid Cells
Chronological Age-Grading of House Flies by Using Near-Infrared Spectroscopy
Distinct Promoters Determine Alternative Transcription of gpx-4 into Phospholipid Hydroperoxide Glutathione Peroxidase Variants
Dual Role of Phagocytic NADPH Oxidase in Bacterial Killing
FceRI Signaling of Mast Cells Activates Intracellular Production of Hydrogen Peroxide: Role in the Regulation of Calcium Signals
Hypoxia Diminishes Toll-Like Receptor 4 Expression Through Reactive Oxygen Species Generated by Mitochondria in Endothelial Cells
Identification and Confirmation of a Module of Coexpressed Genes
Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling
Importance of Histamine in the Cytokine Network in the Lung Through H2 and H3 Receptors: Stimulation of IL-10 Production
In Vivo Neutralization of TNF- Promotes Humoral Autoimmunity by Preventing the Induction of CTL
Lactic acid permeabilizes gram-negative bacteria by disruping the outer membrane
Minodronate, a Newly Developed Nitrogen-Containing Bisphosphonate, Suppresses Melanoma Growth and Improves Survival in Nude Mice by Blocking Vascular Endothelial Growth Factor Signaling
Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis
New Insights on How Metals Disrupt Amyloid -Aggregation and Their Effects on Amyloid- Cytotoxicity
Post-translationally Modified S12 is Not Associated with the 26S Proteasome and Localizes in the Nucleus in Normal, but not Transformed, Breast Epithelial Cells
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
Savignygrin, a Platelet Aggregation Inhibitor from the Soft Tick Ornithodoros savignyi, Presents the RGD Integrin Recognition Motif on the Kunitz-BPTI Fold
The Conformationally Flexible S9-S10 Linker Region in the Core Domain of p53 Contains a Novel MDM2 Binding Site Whose Mutation Increases Ubiquitination of p53 in Vivo
The Cytoplasmic Domain of L-Selectin Participates in Regulating L-Selectin Endoproteolysis
The Increase in TNF-α Levels is Implicated in NF-κB Activation and Inducible Nitric Oxide Synthase Expression in Brain Cortex after Immobilization Stress
The N Terminus of ClpB from Thermus thermophilus is not Essential for the Chaperone Activity
The Peroxisome Proliferator-activated Receptor δ Promotes Lipid Accumulation in Human Macrophages
The Receptor for Advanced Glycation End Products is Induced by the Glycation Products Themselves and Tumor Necrosis Factor-α through Nuclear Factor-κB, and by 17β-Estradiol through Sp-1 in Human Vascular Endothelial Cells
The Zinc Ion in the HNH Motif of the Endonuclease Domain of Colicin E7 is not Required for DNA Binding but is Essential for DNA Hydrolysis
Tumoricidal Activity of Endothelial Cells. Inhibition of Endothelial Nitric Oxide Production Abrogates Tumor Toxicity Induced by Hepatic Sinusoidal Endothelium in Response to B16 Melanoma Adhesion In Vitro
Vasopressin Induces Vascular Superoxide Via Endothelin-1 in Mineralocorticoid Hypertension
Vesicular Restriction of Synaptobrevin Suggests a Role for Calcium in Membrane Fusion
p62 Overexpression in Breast Tumors and Regulation by Prostate-Derived Ets Factor in Breast Cancer Cells

Multiskan FC

Multiskan Spectrum

Varioskan Flash

Appliskan

Fluoroskan Ascent FL