|
| Announcing the
Finnigan™ LXQ™ Linear Ion Trap Mass
Spectrometer |
|
| Announcing the Finnigan
LXQ, a new cost-effective linear ion trap mass spectrometer
that delivers high performance for rapid, reliable analysis
supporting high-throughput solutions for today's fast paced
analytical laboratory. The LXQ provides superior speed and
sensitivity over 3D ion traps, combined with the ruggedness
that Finnigan ion traps have delivered for years. |
| Read Full
Article |
| Tip
of the Month: Verify your Ion Guage Reading |
|
 |
The ion gauge
reading for a Finnigan LTQ™ ion trap mass spectrometer is
typically ~0.8 E-5 torr at 275°C heated capillary temperature.
If the reading that you observe is higher, e.g. 2.0 E-5 torr,
then your Helium tank is either closed or empty. |
| |
| Webinar:
Identification of Biotransformations using Ion
Traps |
|
Speaker: Gargi
Choudhary, Ph.D., Senior Applications
Scientist
Agenda: This webinar will show that
Automated Data Dependent Constant Neutral Loss (DDCNL) Scan
Function is a powerful tool that increases the selectivity for
identification of modifications exhibiting a characteristic
mass shift. This technique can be used for the analysis of
post translational modifications, drug biotransformations, and
can also be applied to the analysis of other classes of
compound transformations, such as degradation or by-product
analyses. It simplifies the analysis of complex mixtures in
biological matrices, and enables rapid characterization of low
abundance species. |
 |
| Register
Now |
| Quantum Waves:
Preclinical Bioanalysis with Animal Models (Contributor: Pete
Kissinger, Ph.D.) |
|
"Thermo instruments have
helped our company make major advances in the way rodents are
utilized for early in vivo screening. We have been able to
dramatically reduce the number of animals required to acquire
quality data by obtaining complete PK curves from individual
animals and by simultaneously, in parallel, acquiring PD data.
Furthermore, the quality of the data is enhanced by
automation. Dosing, collection of samples (blood, urine,
feces, microdialysates in central or peripheral tissue) and
acquisition of PD data are all carried out without human
intervention. Why is this important? Because human
interaction with rodents stimulates animal stress, which
alters the data we need to obtain. How is this advance
possible? Because the Thermo LCQ and TSQ Quantum series of
instruments enable the analysis of smaller volume samples via
lower limits of quantitation, along with very flexible
software for metabolite identification. We especially like the
MSn feature of ion traps and the unique H-SRM (Highly
Selective Reaction Monitoring) capability of the Quantum. We
now have over five years of experience proving these points in
our contract research laboratories, which serve drug discovery
companies as well as big pharma. Not only that, but many of
our client companies have done so as well at their own R&D
sites in the USA and Europe."
-- Pete Kissinger, Ph.D.,
Chairman and CEO, Bioanalytical Systems, Inc; Professor of
Chemistry, Purdue University (These are the personal views of Prof. Kissinger and do
not represent endorsement by Purdue University.) |
| Download Full
Article on Preclinical Bioanalysis with Animal Models (PDF
2134 kB) |
| Contribute to
Critical Mass |
|
 |
Critical Mass is
now accepting contributions from subscribers. If selected for
publication, contributors will receive a Thermo-branded
momento as a token of our appreciation. You are welcome to
send contributions in all areas of Mass Spectrometry. Critical
Mass will accept a wide range of contributions including but
not limited to Your Research Interests in Mass Spectrometry or
using Mass Spectrometry, Tips, New Applications, Interesting
Stories on using Thermo's Mass Spectrometers, etc. Please
click on the link provided below to read the Terms and
Conditions for making contributions. |
| Read Terms and
Conditions for Making
Contributions |
|
| Proteomics Seminars -
North America |
|
 |
| Announcing a FREE One-Day
Seminar featuring the latest research on Top-Down Proteomics,
Quantitative Proteomics, Biomarker Discovery, and PTM Analysis
using the new 2D ion trap, the Finnigan LXQ and the
breakthrough hybrid mass spectrometer, the LTQ Orbitrap™. Specific topics may include:
Benefits of high mass accuracy in biomarker discovery,
Top-down sequencing using FTMS, Eliminating low mass cut-off
using PQD... |
| View Schedule and
Register for North America Proteomics
Seminars |
|
|
| Proteomics Seminars -
Europe |
|
 |
| Announcing a FREE one-day
seminars feature presentations by customers as well as Thermo
application specialists who will share their experiences and
highlight the latest applications and techniques for a range
of topics relating to Proteomics and Biomarker Discovery.
Specific topics include Biomarkers of myocardial infarction,
Quantification strategies using ion trap technology,
Determination of hetero-elements in proteins using
high-resolution ICP-MS... |
| View Schedule and
Register for the European Proteomics
Seminars |
|
| FAIMS: A Tool for
Accelerating LC/MS Method Development |
|
| LC-MS/MS is a highly
selective technique for bioanalysis, but for challenging
assays, more selectivity may be beneficial. Background
interferences, co-eluting isobaric ions, long analytical run
times, and poor ion fragmentation characteristics lead
researchers back to the drawing board. Redeveloping and
validating assays is time consuming and costly, with no
guarantee of success. FAIMS is a unique problem solving tool
for LC-MS method development enabling... |
 |
| Read Full
Article |
| Trap
Talk: Dynamic Range of Accurate Mass in
FTMS |
|
 |
The dynamic range
over which accurate measurements of mass can be made is a key
analytical figure-of-merit. With accurate-mass analyzers
coupled to LC devices, it is important to determine the range
of intensities over which accurate masses can be determined
for transient signals. For all analyzers, mass accuracy is
limited statistically by too few ions, or by peak position
shifts due to too many ions. This work investigates extension
of the dynamic range over which accurate masses can be
determined (dynamic range of mass accuracy) for on-line
experiments using a novel FTMS mass spectrometer (LTQ
Orbitrap). |
| Download Full
Article (PDF
284kB) |
|
|
|
|
|
|
 |
|
|
|