|
|
|
|
|
|
 |
|
Life Science Mass Spectrometry
| Tip of the Month: Multiple Mass Defect Filtering for Metabolite Identification |
 |
By maximizing the power of Multiple Mass Defect Filtering, or MMDF, Thermo Scientific MetWorks software utilizes the superior accurate mass capabilities of the LTQ Orbitrap to simplify and accelerate the search for expected and unexpected biotransformations. With the results provided by MMDF, users at all levels can confidently identify metabolites even when they’re 3-4 orders of magnitude less abundant than the background matrix ions.
» Watch Video Now [4 min 19 sec]
|
| On-Demand Webinar: Metabolomics Analytical Solution - A Tea Plant Nutrition Case Study |
|
Metabolomics is the qualitative and quantitative study of endogenous small molecule patterns that relate to a biological phenotype. The complete Thermo Scientific analytical solution for metabolomics research enables the robust and reproducible GC/MS and LC/MS analysis of complex samples. The metabolomics workflow is highlighted by a case study that compares the metabolite profiles in treated and untreated tea plants.
» Register Now to View this On-Demand Webinar
|
|
| Proteomics: Analysis of Mitotic Phosphorylation Sites in the Nuclear Pore Complex Using a Thermo Scientific MALDI LTQ Orbitrap Mass Spectrometer |
|
The nuclear pore complex (NPC) is an assembly of about thirty proteins that forms the principal passageway for nucleo-cytoplasmic macromolecular traffic. In higher eukaryotes, the NPC undergoes regulated mitotic disassembly into sub-complexes, a process thought to be enacted largely via phosphorylation. In this study, antibodies were used to isolate mitotic NPC sub-complexes, and map mitotic phosphorylation sites in their constituent proteins.
|
A schematic depiction of the assembled (interphase) nuclear pore complex (NPC)
|
|
» Download Full Article [PDF 826 kB]
|
|
| Sample Preparation: HyperSep™ Retain™ Polymeric SPE |
| Thermo Scientific HyperSep Retain polymeric solid phase extraction products offer fast throughput and high reproducibility and recovery for sample preparation prior to LC/MS analysis. HyperSep Retain PEP provides balanced retention of polar and non-polar analytes, while HyperSep Retain-AX and HyperSep Retain-CX provide exceptional recovery for polar acids and bases respectively. All HyperSep Retain products are available in a range of formats to meet demanding market requirements.
» Download Full Application Note [PDF 147 kB]
|
|
| Separated by Experience eNewsletter |
|
|
Separated by Experience is a bi-monthly eNewsletter featuring new solutions, new products and new ideas to improve your chromatography experience.
Recent Issue - Volume 13
» Subscribe
|
| Food Analysis: High Resolution and Precise Mass Accuracy - A Perfect Combination for Food and Feed Analysis in Complex Matrices |
|
In complex sample matrices (e.g. food, feed, hair, honey) limited resolution leads to inaccurate mass measurements caused by unresolved background matrix interferences. This application note shows a full scan screening approach using a novel single stage Orbitrap™ mass spectrometer coupled to U-HPLC, capable of providing high mass accuracy at resolutions of up to 100,000.
» Download Full Article [PDF 482 kB]
|
|
| Over 3600 Searchable Abstracts for Thermo Scientific LC-MS Applications |
|
|
Enhance your technical knowledge with this searchable CD featuring over 3600 LC-MS abstracts from over 240 peer-reviewed publications. The latest release of this database (Version 1.9) covers the spectrum of mass spectrometry technology and applications, including both large and small molecule analysis. The CD contains sample preparation and instrumentation details for each abstract.
» Request Your CD Now!
|
| Promotional Offer: Trade Up to the Power of Linear Ion Trap Technology |
| Trade in your Thermo Scientific LCQ series ion trap for our industry-leading linear ion trap mass spectrometer technology. Don't miss out on this limited time promotional trade-in offer to improve the analytical capabilities of your laboratory with a new LTQ XL™ ion trap.
Why trade up?
- Experience superior sensitivity
- Extend performance further with an upgrade path to the LTQ Orbitrap XL™
- Generate data faster, with more confident data interpretation from new application-specific software
» Request More Information Now
|
|
| Trap Talk: Single Ion Monitoring with 0.5 ppm Mass Accuracy Coupled with Data Dependent Decisions in Complex LC-MS/MS Runs |
Workflow of FT SIM method
|
Recent work in proteomic research demonstrates the need to identify peptides and proteins in complex mixtures from biological sources at extremely low levels with the highest confidence. This requires the use of a mass spectrometer with high dynamic range and high mass accuracy. Moreover, for MS/MS experiments, fast scan repetition rates at highest sensitivity are needed. As it is well known in mass spectrometry, dynamic range can be gained by sacrificing resolution and mass accuracy. This application note describes an instrument method design that increases the dynamic range without sacrificing mass accuracy.
» Download Full Article [PDF 483 kB]
|
|
|
|
|
|
|
|
|
|
|
|
|
Part of Thermo Fisher Scientific
©2009 Thermo Fisher Scientific Inc. All rights reserved.
This is an advertising message from Thermo Fisher Scientific. Your privacy is important to us. Please review our online privacy policy.
|
|
