|
|
|
|
|
|
 |
|
Life Sciences Mass Spectrometry
| Tip of the Month: Examining SRMs of Multiply Charged Peptides |
 |
When examining SRMs of multiply charged peptides, try looking at higher m/z for fragments. If a highly charged peptide loses a charge during mass fragmentation, the resulting m/z may actually be higher than the m/z for the precursor ion. This is different from small molecule SRMs which are frequently singly charged and only fragment to lower m/z.
» More Proteomics Information [www.thermo.com/proteomics]
|
| Live Webinar: Improve the Results of Your Life Sciences Analysis with Thermo Scientific Linear Ion Trap and Orbitrap Mass Spectrometers (May 14, 2009, 11 A.M. U.S. ET, 6:00 P.M. GMT) |
|
Ion trap and orbitrap mass spectrometers routinely deliver confident protein and metabolite identification, characterization and quantification. Attend this webinar to find out how to maximize these technologies for the analysis of complex mixtures - increasing protein coverage and gaining access to exceptional MSn structural elucidation data. New methodologies for optimizing your analyses will be discussed.
» Learn more and Register
|
|
Register for our Annual ASMS User Meeting and Customer Event
(May 31, 2009, Philadelphia, PA, USA) |
|
|
Join us Sunday May 31st from 8 AM - 12 PM in Philadelphia, PA to find out about new methods and instrumentation for resolving complexity in your mass spectrometry analyses. The annual user meeting will feature a plenary presentation from Jesper Olson, Ph.D, from the Max Planck Institute for Biochemistry, followed by break-out sessions on small molecule and large molecule applications. After an informative morning, we'll transport you to the Moshulu, the largest four-masted sailing ship in the world still afloat, for lunch with unparalleled views of the city and waterfront.
» Register Now!
|
|
Food Safety: Case Study - 17-Minute Online Method for Antibiotics in Honey
|
|
|
Increasing concern over the presence of antibiotics and pesticide residues in foodstuffs and the related potential health threats to humans has driven food quality control laboratories to develop fast and efficient methods of detecting these contaminants. Some of the challenges facing these organizations include their need for multi-component quantitation, preference for simple sample preparation, and desire for an automated, online method to make quality control screening cost-effective.
The team at the Korea Beekeeping Association has automated their method to screen for 50 antibiotics in honey - reducing analysis time by 94%.
» Register to Download Full Case Study [PDF 442 kB]
|
| Proteomics: Absolute Quantitation of Targeted Endogenous Salivary Peptides using Heavy Isotope-labeled Internal Standards and H-SRM |
|
Salivary gland secretions have significant potential as a noninvasive source of disease biomarkers and recent compilations of the salivary protein repertoire became valuable resources for parallel studies focusing on oral and systemic diseases.
In this study, a targeted peptide quantitation assay was created for a Thermo Scientific TSQ Vantage triple quadrupole mass spectrometer to determine the natural abundance of six peptides in sixteen samples from the salivary gland secretions of eight donors.
» Download Full Application Note [PDF 687 kB]
|
|
| Drug Discovery: High Throughput LC-MS/MS Analysis of Metabolic Stability Incubations |
|
|
High throughput screening (HTS) assays are commonly used in the discovery stage of the drug development process where a large number of compounds are screened. Compound optimization and sample analysis are factors that limit throughput. This application note addresses mass spectrometry optimization and sample analysis problems by using the Thermo Scientific Aria TLX-4 multiplexed HPLC system, powered by TurboFlow™ technology, and Thermo Scientific QuickQuan software for the compound optimization process.
» Download Full Application Note [PDF 118 kB]
|
| Chromatography: Porous Graphitic for Sample Preparation and LC/MS Analysis of Hydrophilic Biomolecules |
|
This poster demonstrates the advantages of using Hypercarb porous graphitic carbon (PGC) in micro-scale SPE and LC/MS analysis of polar molecules of biological interest such as small hydrophilic peptides and phosphopeptides.
» Download Poster [PDF 230 kB]
|
|
| Thermo Scientific Life Sciences MS Abstract - Winter 2009 CD-ROM - Now Available!! |
|
|
Enhance your technical knowledge with this searchable CD featuring over 3600 LC-MS abstracts from over 240 peer-reviewed publications. The latest release of this database (Version Winter 2009) covers the spectrum of mass spectrometry technology and applications, including both large and small molecule analysis. The CD contains sample preparation and instrumentation details for each abstract.
» Request Your CD Today!!
|
| Trap Talk: Using Multistage Activation in an Ion Trap Mass Spectrometer |
| In multistage activation (pseudo MS3), the neutral loss ion is collisionally activated while the fragments from the precursor ion are still present in the ion trap mass spectrometer. Because the second ion isolation step is eliminated, the spectrum produced is the combination of MS/MS and MS3 fragmentation and retains the informative fragments from the precursor ion. When compared to a traditional MS3 neutral loss experiment, multistage activation generates spectra with increased signal intensity and a greater number of structurally diagnostic ions.
» Download Full Product Support Bulletin [PDF 216 kB]
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Part of Thermo Fisher Scientific
©2009 Thermo Fisher Scientific Inc. All rights reserved.
This is an advertising message from Thermo Fisher Scientific. Your privacy is important to us. Please review our online privacy policy.
|
|
