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Life Sciences Mass Spectrometry
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Proteomics: Proteome Discoverer 1.1 Software Released
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For researchers working with proteins, revision 1.1 of the Thermo Scientific Proteome Discoverer software was released in December. It offers increased productivity through improved automation, batch processing, and support for large data sets. It also includes support for processing fractionated samples and MudPIT experiments, and for quantitation experiments using tandem mass tags (TMT). Additional information about Proteome Discoverer™ software can be found on the Proteome Discoverer web page or by contacting your local Thermo Scientific product representative.
» View the Presentation Highlighting Some of the New Features [PDF 585 kB]
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Proteomics / Metabolomics: SIEVE Software Brochure Highlights New Features and Capabilities
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Label-free differential analysis is gaining popularity for discovery of protein and metabolite biomarkers. By finding those compounds with statistically significant abundance differences between sample populations, it greatly reduces the number of compounds that need to be identified. Thermo Scientific SIEVE software provides an easy-to-use, automated solution for evaluating the large amounts of LC/MS and GC/MS data generated by label-free differential analyses. The new SIEVE™ software brochure demonstrates how the SIEVE software simplifies and facilitates the entire workflow, and highlights important features of the software such as the proprietary chromatographic alignment algorithm.
» Download the SIEVE Brochure [PDF 1.5 MB]
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On-Demand Webinar: Increase Mass Spec Throughput up to 400%
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Today’s budget-limited LC/MS customers are looking for ways to increase throughput and flexibility of their mass spectrometers without sacrificing data quality or reliability. Multiplexing is a proven technology that can produce these results. View this free webinar to see how you can use multiplexing to increase the throughput of your mass spectrometer.
» Register to View this On-Demand Webinar [53 Minutes]
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Clinical: Research Analysis of Clozapine and Norclozapine in Plasma using Automated Sample Preparation and LC-MS/MS
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Clozapine is a tricyclic dibenzodiazepine drug used in the treatment of schizophrenia. It is uniquely effective in patients resistant to therapy with other antipsychotics. In addition to mandatory hematological monitoring to minimize the risk of agranulocytosis, there are large variations (50-fold) among patients’ clozapine dose requirements. Moreover, changes in smoking habits can have a large effect on the clozapine dose requirement (on average, the clozapine dose for non-smokers is half that required for smokers) due to the induction of cytochrome P450 (CYP) enzymes in smokers. Studies have indicated that accurate quantification of clozapine levels may help researchers better understand, and conduct analysis of, issues related to dose optimization and adherence.
This application note demonstrates the use of the automated TurboFlow method effectively eliminated two hours of sample preparation time for a 100-sample batch.
» Register to Download Complete Application Note [PDF 414 kB]
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Environmental: Analysis of Sulfonamides in River Water using EQuan, an Online Concentration Analysis System
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Triple stage quadrupole LC-MS systems are often used for highly sensitive quantitative analysis of environmental pollutants. The performance of an LC-MS system is one important factor that determines if it will efficiently and accurately detect pollutants present at low concentrations in environmental samples. Another factor is the process by which the system pre-treats the samples. In its sample pretreatment process, the Thermo Scientific EQuan system is able to quickly perform the time-consuming concentration process online, dramatically reducing the time required for analysis. Consequently, EQuan™ is capable of measuring multiple samples more efficiently than systems using off-line sample preparation, while reaching lower detection limits than are achievable with a conventional LC-MS/MS analysis.
» Download Complete Application Note [PDF 703 kB]
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NEW Thermo Scientific Chromatography Columns and Consumables Catalog
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The 2010 - 2012 Thermo Scientific Chromatography catalog showcases the broadest collection of chromatography columns and consumables. Over 500 new pages of high quality tools ensure unrivalled choice for all separation needs.
» Order Your Copy of the Catalog Today!
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Trap Talk: Improving the ETD Reagent Ion Intensity on Your Thermo Scientific Orbitrap
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Many things can affect the reagent ion intensity on Electron Transfer Dissociation (ETD) instruments. If the reagent ion intensity drops below 5e5 in profile mode it is necessary to tune and/or calibrate the ETD components of the instrument. To improve the reagent ion intensity to a good level (generally > 1e6 in profile mode) follow this list of helpful hints.
» Download List of Helpful Hints [PDF 18 kB]
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